wet granulation nucleation regime theory

  • (67d) Mapping of Nucleation Mechanisms for …

    Wet granulation is the process of adding a liquid binder to a fine powder in order to get larger granules for improved particle properties. This process is used in a variety of industries, including pharmaceuticals, food, agricultural chemicals, and detergents. The typical industrial equipment used for this process includes high shear mixers, drums, pans, and fluid beds. Currently, many of the ...

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  • Effects of Process and Design Parameters on …

    The granulation mechanism underlying this continuous process was examined using a wetting and nucleation regime map. For the cases studied here, the mechanical dispersion regime controlled the formation of granule nuclei, leading to a broad GSD and a limited growth ratio. Wet granulation is widely used in the pharmaceutical industry. This advantageous technology is capable of enhancing ...

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  • Granulation of hydrophobic powders - …

    Essential to this theory is that wetting and spreading of the fluid through the powder particles is a prerequisite for good granulation. The possibility of a fine, hydrophobic powder spreading over the surface of the liquid during nucleation has been identified theoretically based on surface chemistry and as a potential nucleation mechanism. Recently, investigation confirmed that nucleation ...

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  • Improved Understanding of the High Shear Wet Granulation ...

    implemented based on a nucleation regime map approach. Results: According to the Plackett–Burman experimental design, it was found that three granulation factors, including salvia ratio, binder amount, andchopperspeed,significantlya ectedthegranulesize(D50)ofS.miltiorrhizainHSWG.Furthermore, the results of the Box–Behnken experimental design and validation experiment showed that the model ...

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  • Scale-up of a high shear wet granulation process …

    For the HSWG process, formulation design and process scale-up can be undertaken with a regime map approach based on dimensional analysis. In regime map theory, as proposed by Iveson and Litster (1998), the rate processes for HSWG consist of wetting and nucleation, coalescence and growth, and breakage.Because the growth regime map is based on operating in the drop-controlled regime for …

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  • Advanced Granulation Theory at Particle Level

    Advanced granulation theory at particle level 6 the primary interest. In recent work by Wildeboer et al. (2005) they introduced another similar parameter being the nucleation area ratio according to: d n a a a K (1.1) where an is the projected area of the nuclei granules and ad is the projected area of the binder droplets. Although not very ...

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  • A priori performance prediction in pharmaceutical …

    14/10/2011· A priori performance prediction in pharmaceutical wet granulation: testing the applicability of the nucleation regime map to a formulation with a broad size distribution and dry binder addition. Kayrak-Talay D(1), Litster JD. Author information: (1)School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.

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  • Scale-up of a high shear wet granulation process …

    Scale-up of a high shear wet granulation process using a nucleation regime map approach Article (PDF Available) in Particuology 31 · September 2016 with 1,079 Reads How we measure 'reads'

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  • Nucleation, growth and breakage phenomena in …

    Nucleation, growth and breakage phenomena in agitated wet granulation processes: A review Article in Powder Technology 117(1-2) · June 2001 with 456 Reads How we measure 'reads'

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  • Nucleation and Binder Dispersion in Wet …

    Nucleation is the first step in granulation where the powder and liquid first contact. Two types of nucleation in wet granulation processes are proposed. Drop controlled nucleation, where one drop ...

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  • Granulation and Tabletting | SpringerLink

    Abstract. This chapter provides an overview of the granulation and tabletting processes, with a focus on wet granulation. The emphasis is on the applications of wet granulation, including practical advice for the design, operation, and control of the equipment, as well as specific industrial applications.

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  • Modelling nucleation in wet granulation | …

    Modelling nucleation in wet granulation. Article in Chemical Engineering Science 60(14):3751-3761 · July 2005 with 110 Reads How we measure 'reads' A 'read' is counted each time someone views a ...

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  • Peter Dybdahl Hede - Amazon S3

    Advanced Granulation Theory at Particle Level 7 Fluid bed agglomeration at particle level 1.2 Wetting and nucleation The initial step in the wet agglomeration processes is the process of bringing liquid binder into contact with

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  • Particle Growth And Agglomeration Processes

    Regime maps 4.1 Nucleation regime map 4.2. Granulation regime map 5. Population balance equations 6. Granulation Equipment 6.1. Drum granulation 6.2. Pan granulation 6.3. Fluidized bed granulation 6.4. High Shear Mixer Granulators 6.5. Dry Granulation 6.5.1. Roll compaction 6.5.2. Direct compression 7. Equipment design 8. Conclusion Glossary Bibliography Summary Agglomeration is a …

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  • Nucleation, growth and breakage phenomena in …

    Nucleation is the first step in granulation where the binder begins to wet the powder and form initial agglomerates. Whether or not wetting is energetically favourable is driven by thermodynamics. Studies of wetting thermodynamics have focused on two aspects: the contact angle between the solid and the binder, and the spreading coefficients of the liquid phase over the solid phase and vice versa.

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